General Information

  • ID:  hor005188
  • Uniprot ID:  P47213
  • Protein name:  Galanin
  • Gene name:  gal
  • Organism:  Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
  • Family:  Galanin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GWTLNSAGYLLGPHGIDGHRTLSDKHGLA
  • Length:  29(1-29)
  • Propeptide:  GWTLNSAGYLLGPHGIDGHRTLSDKHGLA
  • Signal peptide:  NA
  • Modification:  T29 Alanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  the peptide may exercise an important role in the regulation of neuroendocrine functions, particularly those related to reproduction.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P47213-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P47213-F1.pdbhor005188_AF2.pdbhor005188_ESM.pdb

Physical Information

Mass: 354402 Formula: C135H207N41O40
Absent amino acids: CEFMQV Common amino acids: G
pI: 7.8 Basic residues: 5
Polar residues: 12 Hydrophobic residues: 9
Hydrophobicity: -36.55 Boman Index: -2950
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 87.59
Instability Index: -751.72 Extinction Coefficient cystines: 6990
Absorbance 280nm: 249.64

Literature

  • PubMed ID:  7532194
  • Title:  Characterization of trout galanin and its distribution in trout brain and pituitary.